Biophysical characterization of proteins in developing biopharmaceuticals 2nd Edition by Damian J. Houde
Publisher: Elsevier (S&T)
Print ISBN: 9780444641731, 0444641734
eText ISBN: 9780444641748, 0444641742
Copyright year: 2020
Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals.
In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical’s developability and the technical decision-making process needed when dealing with biophysical characterization data.
Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development
Highlights the capabilities and limitations of each technique
Discusses the underlining science of each tool
Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools
Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry
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